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Home›Health›The World gets closer to coronavirus cure as another vaccine trial enters final stage this month

The World gets closer to coronavirus cure as another vaccine trial enters final stage this month

By alternativeafrica
July 15, 2020
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London, July 15, 2020 (AltAfrica)-The race for a permanent cure for coronavirus gets closer each day after US biotech firm Moderna said Tuesday it would enter the final stage of human trials for its COVID-19 vaccine on July 27, after promising early results were published in an influential journal.

Neal Browning gets a shot of the potential vaccine. Now the World gets closer to coronavirus cure as another vaccine trial enters final stage this month Image: AP Photo/Ted S. Warre

The Phase 3 trial will recruit 30,000 participants in the US, with half to receive the vaccine at 100 microgram dose levels, and the other half to receive a placebo.

It is designed to show whether the vaccine is safe and can prevent infection by the SARS-CoV-2 virus, or — if people still get infected — whether it can prevent the infection progressing toward symptoms

If they do get symptoms, the vaccine can still be considered a success if it stops severe cases of COVID-19.

READ ALSO: SOUTH AFRICA SURPASSES UK IN CONFIRMED COVID-19 CASES

The study should run until October 27, according to its page on clinicaltrials.gov.

The announcement came after the New England Journal of Medicine on Tuesday published results from the first stage of Moderna’s vaccine trial, which showed the first 45 participants all developed antibodies to the virus.

Moderna, currently in the middle stage, is considered to be in a leading position in the global race to find a vaccine against the coronavirus, which has infected more than 13.2 million people and killed 570,000.

China’s SinoVac is also at Phase 2.

Russian news agency TASS on Sunday announced Russian researchers have completed clinical trials on a vaccine, though they have not shared their data.

Scientists caution that the first vaccines to come to market may not be the most effective or safest.

– ‘Encouraging’ results –

Moderna had previously published “interim results” from the first stages of its trial, called Phase 1, in a press release on its website in May.

These revealed the vaccine had generated immune responses in eight patients, a result called “encouraging” by Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, which is co-developing the vaccine.

But some in the scientific community said they would reserve judgment until they saw the full results in peer-reviewed form.

According to the new paper, 45 participants were split into three groups of 15 each to test doses of 25 micrograms, 100 micrograms and 250 micrograms.

They were given a second dose of the same amount 28 days later.

After the first round of vaccine trial, antibody levels were found to be higher with higher doses.

Following the second round, participants had higher levels of antibodies than most patients who have had COVID-19 and gone on to generate their own antibodies.

More than half the participants experienced mild or moderate side effects, which is considered normal.

The side effects included fatigue, chills, headache, body ache and pain at the injection site.

Three participants did not receive their second dose.

They included one who developed a skin rash on both legs, and two who missed their window because they had COVID-19 symptoms, but their tests later returned negative.

“The results look pretty good and look pretty consistent,” David Lo, a professor of biomedical sciences at University of California Riverside told AFP.

But he cautioned that more work was needed to evaluate the vaccine’s safety — including making sure that it did not backfire by eventually making the immune system “tolerant” toward the real virus.

Amesh Adalja, an infectious diseases specialist at Johns Hopkins University, added it was encouraging that the participants developed high levels of an advanced class of antibodies.

He added, however: “You have to be very limited in how much you can extrapolate from a phase one clinical trial, because you want to see how this works when a person is exposed to the actual virus.”

The Moderna vaccine belongs to a new class of vaccine that uses genetic material — in the form of RNA — to encode the information needed to grow the virus’s spike protein inside the human body, in order to trigger an immune response.

The spike protein is a part of the virus that it uses to invade human cells, but by itself the protein is relatively harmless.

The advantage of this technology is that it bypasses the need to manufacture viral proteins in the lab, shaving months off the standardization process and helping to ramp up mass production.

No vaccines based on this platform have previously received regulatory approval.

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